Recent Developments in Mendelian Randomization Studies
نویسندگان
چکیده
منابع مشابه
Recent Developments in Mendelian Randomization Studies
Purpose of Review Mendelian randomization (MR) is a strategy for evaluating causality in observational epidemiological studies. MR exploits the fact that genotypes are not generally susceptible to reverse causation and confounding, due to their fixed nature and Mendel's First and Second Laws of Inheritance. MR has the potential to provide information on causality in many situations where random...
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In Mendelian randomization (MR) studies, where genetic variants are used as proxy measures for an exposure trait of interest, obtaining adequate statistical power is frequently a concern due to the small amount of variation in a phenotypic trait that is typically explained by genetic variants. A range of power estimates based on simulations and specific parameters for two-stage least squares (2...
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Epidemiological research over the last 50 years has discovered a plethora of biomarkers (including molecules, traits or other diseases) that associate with coronary artery disease (CAD) risk. Even the strongest association detected in such observational research precludes drawing conclusions about the causality underlying the relationship between biomarker and disease. Mendelian randomization (...
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BACKGROUND Observational epidemiology has been instrumental in identifying modifiable causes of common diseases, and, in turn, substantially impacting public health. Spurious associations in observational epidemiologic studies are most commonly caused by confounding due to social, behavioral, or environmental factors and can therefore be difficult to control. They may also be due to reverse cau...
متن کاملMendelian randomization: genetic anchors for causal inference in epidemiological studies
Observational epidemiological studies are prone to confounding, reverse causation and various biases and have generated findings that have proved to be unreliable indicators of the causal effects of modifiable exposures on disease outcomes. Mendelian randomization (MR) is a method that utilizes genetic variants that are robustly associated with such modifiable exposures to generate more reliabl...
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ژورنال
عنوان ژورنال: Current Epidemiology Reports
سال: 2017
ISSN: 2196-2995
DOI: 10.1007/s40471-017-0128-6